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A statistical information site that deepens the understanding of AMR (drug resistance) and one health

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Monitoring on the antimicrobial-resistant Salmonella Typhi, Salmonella Paratyphi A, and Shigella spp.

1) Overview

For typhoid, paratyphoid, and shigellosis, definitive diagnosis is undertaken based on bacterial isolation. Given there are no routine antimicrobial resistance monitorings regarding Salmonella Typhi, Salmonella Paratyphi A, and Shigella spp, susceptibility tests are performed at the National Institute of Infectious Diseases, using strains submitted based on the Notification for Epidemiological Surveillance. Antimicrobial resistance information concerning Shigella spp. is also used as data reported to GLASS.

2) Methods

Antimicrobial susceptibility tests are performed using strains that are submitted based on the Notification for Epidemiological Surveillance (HSB/TIDCD Notification No. 100901, PFSB/ISD Notification No. 100902). In antimicrobial susceptibility tests, assessment was performed in accordance with CLSI standards, using a broth microdilution method for Salmonella Typhi and Salmonella Paratyphi A, and using a disk diffusion method for Shigella spp.

3) Prospect

Treatment with antimicrobials is essential for typhoid and paratyphoid. To enable the proper selection of effective therapeutic agents, it is necessary to conduct continuous monitoring. The proportion of strains that are resistant to quinolones and other commonly used antibacterials are high in Shigella spp, and therefore recurrence is also possible even after administering antimicrobials. Careful monitoring is required to prevent possible spread of infection in Japan.